Prognostic Significance of Apocrine Differentiation in Breast Cancer
Author Information
Author(s): N.J. Bundred, R.A. Walker, D. Everington, G.K. White, H.J. Stewart, W.R. Miller
Primary Institution: University of Leicester and University of Edinburgh
Hypothesis
Does apocrine differentiation in breast carcinoma have prognostic significance?
Conclusion
Apocrine differentiation in breast cancer is an independent predictor of poor prognosis.
Supporting Evidence
- Patients with apocrine staining had a shorter disease-free interval.
- Apocrine differentiation was unrelated to lymph node status, menstrual status, tumor grade, or size.
- Presence of apocrine staining added significantly to the predictive value of other prognostic factors.
Takeaway
This study found that certain breast cancer cells have a special feature called apocrine differentiation, which can mean a worse outcome for patients.
Methodology
The study assessed breast tumor samples using immunohistochemistry to detect apocrine differentiation and related findings to standard prognostic factors.
Limitations
The study did not find significant associations between apocrine differentiation and several other prognostic factors.
Participant Demographics
145 women with early breast cancer, minimum follow-up of 5 years.
Statistical Information
P-Value
P = 0.03
Statistical Significance
p<0.05
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