Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
2001
Significance of erb-B Receptors in Liver Cancer
publication
Author Information
Author(s): Ito Y, Takeda T, Sakon M, Tsujimoto M, Higashiyama S, Noda K, Miyoshi E, Monden M, Matsuura N
Primary Institution: Osaka University
Hypothesis
The study investigates the clinical significance of the erbB family in hepatocellular carcinoma (HCC).
Conclusion
EGF-R and c-erbB-3 are important in the progression of HCC, while c-erbB-2 showed no relationships with clinicopathological parameters.
Supporting Evidence
- EGF-R was expressed in 68% of the HCC examined and correlated with various clinical parameters.
- c-erbB-3 was observed in 84% of HCC cases and was related to multiple clinicopathological features.
- c-erbB-2 was expressed in only 21% of cases and showed no relationships with clinicopathological parameters.
- c-erbB-4 was expressed in 61% of HCC but was less than in adjacent noncancerous lesions in 51.2% of cases.
Takeaway
This study looked at how certain proteins are related to liver cancer and found that two of them are important for understanding the disease.
Methodology
The expression of erbB family proteins was investigated using immunohistochemistry in HCC and adjacent noncancerous lesions.
Digital Object Identifier (DOI)
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