Modular CAR-T Platforms: A Comprehensive Review
Author Information
Author(s): Mohammad Afraa, Yurina Anna, Simonyan Tatiana, Chistyakov Daniil, Salman Rand, Zornikova Ksenia, Minina Elizaveta, Bogolyubova Apollinariya
Primary Institution: National Medical Research Center for Hematology, Moscow, Russia
Hypothesis
This systematic review seeks to evaluate the different parameters of modular CAR-T platforms performance in animal models.
Conclusion
The modular CAR-T platforms are generally effective and are a valuable addition to the arsenal of CAR therapy.
Supporting Evidence
- 33 studies employing 15 different modular CAR-T platforms were included.
- The studies showed a reduction in tumor burden and in tumor volume compared to the combined negative group.
- In all the included studies, the experimental group had a higher survival probability compared to the combined negative group at the study endpoint.
Takeaway
This study looks at new types of CAR-T therapies that can target multiple cancer markers and help treat tumors better.
Methodology
A systematic search of literature in the PubMed database and in Google Scholar and BASE was performed according to predefined eligibility criteria.
Potential Biases
High risk of bias concerning sequence generation and allocation concealment; unclear risk of bias in random housing and outcome assessment.
Limitations
The study did not fully represent all of the modular CAR T platforms that are currently available due to the variety of platforms, targeted antigens, experimental designs, and xenograft models employed.
Participant Demographics
The studies primarily used xenograft mouse models, with a median age of 7 weeks and a total of 1595 mice across all studies.
Statistical Information
P-Value
p<0.05
Digital Object Identifier (DOI)
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