Expression of a Constitutively Active Calcineurin Encoded by an Intron-Retaining mRNA in Follicular Keratinocytes
2011
Calcineurin Activation and Hair Development
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Fujimura Atsushi, Michiue Hiroyuki, Nishiki Tei-ichi, Ohmori Iori, Wei Fan-Yan, Matsui Hideki, Tomizawa Kazuhito
Primary Institution: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hypothesis
The calcineurin/NFAT pathway has a unique regulatory role in hair follicle development.
Conclusion
Inhibition of the calcineurin/NFAT signaling pathway enhances hair growth.
Supporting Evidence
- Calcineurin Aß-FK is predominantly expressed in mature follicular keratinocytes.
- Inhibition of Cn/NFAT induced hair growth in nude mice.
- Cyclin G2 was identified as a novel target of the Cn/NFATc2 pathway.
- Overexpression of cyclin G2 arrested the cell cycle in follicular keratinocytes.
Takeaway
This study found that a specific protein variant helps control hair growth, and blocking its activity can make hair grow more.
Methodology
The study involved cell culture, animal studies, and various assays to analyze gene expression and protein activity.
Statistical Information
P-Value
p<0.0005
Statistical Significance
p<0.0005
Digital Object Identifier (DOI)
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