Effect of Oxygen Levels on Surgical Infections
Author Information
Author(s): Meyhoff Christian S, Wetterslev Jørn, Jorgensen Lars N, Henneberg Steen W, Simonsen Inger, Pulawska Therese, Walker Line R, Skovgaard Nina, Heltø Kim, Gocht-Jensen Peter, Carlsson Palle S, Rask Henrik, Karim Sharaf, Carlsen Charlotte G, Jensen Frank S, Rasmussen Lars S
Primary Institution: Copenhagen University Hospital, Rigshospitalet
Hypothesis
Does a high perioperative oxygen fraction reduce the risk of surgical site infections and pulmonary complications after abdominal surgery?
Conclusion
The trial aims to determine if high levels of oxygen during surgery can lower the risk of infections and other complications.
Supporting Evidence
- A high oxygen fraction may reduce surgical site infections by improving wound oxygen tension.
- Previous trials showed mixed results regarding the effect of high oxygen levels on infections.
- The study includes a large sample size to enhance the reliability of the findings.
Takeaway
This study is like testing if giving more oxygen during surgery helps patients heal better and get fewer infections.
Methodology
A randomized, patient- and assessor-blinded trial comparing 80% oxygen to 30% oxygen in 1400 patients undergoing laparotomy.
Potential Biases
Potential bias due to the nature of the intervention and patient allocation.
Limitations
Some patients may not receive the exact oxygen levels as allocated, and not all standard treatments can be applied to every patient.
Participant Demographics
Patients aged 18 and older scheduled for acute or elective laparotomy.
Statistical Information
P-Value
0.57
Confidence Interval
95% CI: -68% to 61%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website