Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model
2007
Phenoxodiol Protects Neurons from Cisplatin Damage
publication
Evidence: moderate
Author Information
Author(s): Reuben Klein, David Brown, Ann M Turnley
Primary Institution: Centre for Neuroscience, The University of Melbourne
Hypothesis
Can phenoxodiol protect against Cisplatin-induced neurite toxicity in PC12 cells?
Conclusion
Phenoxodiol may help prevent neuropathy caused by Cisplatin chemotherapy.
Supporting Evidence
- Phenoxodiol at low concentrations blocked Cisplatin-induced neurite toxicity.
- Cisplatin caused significant neurite toxicity, which was mitigated by phenoxodiol.
- Phenoxodiol did not restore neurite outgrowth after Cisplatin treatment.
Takeaway
This study found that a drug called phenoxodiol can help protect nerve cells from damage caused by a cancer treatment called Cisplatin.
Methodology
PC12 cells were treated with Cisplatin and phenoxodiol, and neurite outgrowth was measured to assess toxicity.
Limitations
The study was conducted in vitro, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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