Genistein and Drug Resistance in Tumor Cells
Author Information
Author(s): C.H.M. Versantvoort, G.J. Schuurhuis, H.M. Pinedo, C.A. Eekman, C.M. Kuiper, J. Lankelma, H.J. Broxterman
Primary Institution: Free University Hospital
Hypothesis
Can genistein reverse decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumor cells?
Conclusion
Genistein effectively increases drug accumulation in non-Pgp MDR cells but not in Pgp MDR cells.
Supporting Evidence
- Genistein increased daunorubicin accumulation in non-Pgp MDR cell lines.
- Genistein had no significant effect on drug accumulation in Pgp MDR cells.
- Other flavonoids also increased drug accumulation in non-Pgp MDR cells.
Takeaway
Genistein helps some cancer cells take in more medicine, making it easier to treat them, but it doesn't work for all types of resistant cancer cells.
Methodology
The study examined the effects of genistein on drug accumulation in various non-Pgp and Pgp MDR cell lines using drug accumulation assays.
Limitations
The cytotoxic effects of genistein were too high for continuous exposure in drug cytotoxicity experiments.
Statistical Information
P-Value
p<0.02
Statistical Significance
p<0.02
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