Case Report on Pemphigus Vulgaris Treatment with a Peptide
Author Information
Author(s): Angelini Giovanni, Bonamonte Domenico, Lucchese Alberta, Favia Gianfranco, Serpico Rosario, Mittelman Abraham, Simone Simone, Sinha Animesh A, Kanduc Darja
Primary Institution: University of Bari, Italy
Hypothesis
Can a proteomics-derived peptide effectively treat Pemphigus vulgaris without adverse effects?
Conclusion
Topical treatment with the Dsg349–60REWVKFAKPCRE peptide may be a promising and safe approach for treating Pemphigus vulgaris.
Supporting Evidence
- The treated lesion showed a higher rate of re-epithelization compared to the non-treated area.
- The patient experienced a decrease in anti-Dsg antibody titer after treatment.
- No adverse effects were reported during or after the treatment.
Takeaway
This study shows that a special cream with a peptide can help heal skin lesions in a patient with a serious skin disease called Pemphigus vulgaris without causing any bad side effects.
Methodology
The peptide was applied topically for one week on a lesion of a patient with late-stage Pemphigus vulgaris.
Limitations
This is a preliminary case report with only one patient, limiting the generalizability of the findings.
Participant Demographics
One 56-year-old male patient with a history of Pemphigus vulgaris.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website