Study on Extended Spectrum β-lactamase Producing Enterobacteriaceae
Author Information
Author(s): Rudresh S.M. Nagarathnamma
Primary Institution: Victoria Hospital, Bangalore
Hypothesis
The study aimed to determine the presence of ESBLs among Enterobacteriaceae isolates and their antibiotic susceptibility patterns.
Conclusion
The study found that 62.3% of Enterobacteriaceae isolates produced ESBLs, indicating a high prevalence of antibiotic resistance.
Supporting Evidence
- 149 out of 239 isolates (62.3%) were found to be ESBL producers.
- ESBL production was more common among isolates obtained from exudates (70%) and blood (66.7%).
- Imipenem was identified as the most effective drug against ESBL producing organisms.
Takeaway
The study looked at bacteria that can resist certain antibiotics and found that many of them are hard to treat because they have special enzymes.
Methodology
The study included 239 clinical isolates of Enterobacteriaceae, identified and tested for antibiotic susceptibility using standard laboratory methods.
Limitations
The study was limited to isolates from a single hospital and may not represent broader trends.
Participant Demographics
Isolates were obtained from both inpatients (56.9%) and outpatients (43.1%) at Victoria Hospital, Bangalore.
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