HPV and Genetic Factors in Cervical Cancer
Author Information
Author(s): Cuzick J, Terry G, Ho L, Monaghan J, Lopes A, Clarkson P, Duncan I
Primary Institution: Department of Mathematics, Statistics & Epidemiology, Imperial Cancer Research Fund
Hypothesis
Is there an association between high-risk HPV types, specific HLA alleles, and cervical cancer in British women?
Conclusion
The study found that certain HLA alleles are associated with cervical cancer, particularly in women with HPV types other than HPV16.
Supporting Evidence
- 94% of cervical scrapes tested positive for high-risk HPV types.
- 66% of the samples were positive for HPV16.
- DQB1*0301 was associated with cervical cancer.
- A protective effect was found for DQB1*0501.
Takeaway
The study looked at women with cervical cancer and found that some genetic factors might increase the risk of getting the disease, especially when combined with certain types of HPV.
Methodology
Cervical scrapes from women with cervical cancer were tested for high-risk HPV types and compared with women having normal cytology.
Participant Demographics
British women referred with cervical cancer and a control group of women with normal cytology.
Statistical Information
P-Value
p=0.02, p=0.05, p=0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website