Aseptic Meningitis and White Matter Disease in Childhood-Onset Neuropsychiatric Lupus
Author Information
Author(s): Hsu Mei Lam, Chan Kwai Yu Winnie
Primary Institution: Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong
Conclusion
The patient with neuropsychiatric lupus successfully remitted without residual neurological sequelae after treatment with low-dose intravenous cyclophosphamide and monthly intravenous immunoglobulin.
Supporting Evidence
- The patient had a history of systemic lupus erythematosus and presented with atypical demyelinating disease.
- Extensive microbiological workup for infective meningitis was negative.
- Interval MRI showed resolution of the white matter hyperintensity after treatment.
Takeaway
A 10-year-old girl with lupus had severe brain symptoms but got better after special treatments, showing that lupus can affect the brain in serious ways.
Methodology
The patient was treated with intravenous immunoglobulin and cyclophosphamide, with follow-up MRI scans to assess treatment response.
Limitations
This is a single case report, limiting generalizability.
Participant Demographics
The patient was a 10-year-old girl.
Digital Object Identifier (DOI)
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