Genome Scan for Alcoholism Risk Factors
Author Information
Author(s): Adrienne H Williams, Brown W Mark, Carl D Langefeld
Primary Institution: Wake Forest University Health Sciences
Hypothesis
This study aims to identify genetic regions linked to alcoholism by examining Caucasian genome scan data.
Conclusion
The study found significant evidence for linkage to alcoholism in specific regions of the genome, particularly on chromosomes 7 and 21.
Supporting Evidence
- The study identified four regions of the genome with LOD scores greater than one.
- Evidence for linkage increased among pedigrees with earlier mean age of onset.
- The strongest evidence of linkage was found on chromosome 7.
Takeaway
Scientists looked at the genes of people with alcoholism to find out which parts of their DNA might make them more likely to drink too much.
Methodology
The study used nonparametric linkage regression modeling on genome scan data from Caucasian pedigrees.
Potential Biases
Potential bias due to the limited number of non-Caucasian pedigrees.
Limitations
The study focused only on self-reported Caucasian samples and did not adjust for multiple comparisons across the genome.
Participant Demographics
The sample consisted of 102 Caucasian pedigrees and 41 non-Caucasian pedigrees.
Statistical Information
P-Value
0.0016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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