Study of LytR-CpsA-Psr Protein Family in Bacteria
Author Information
Author(s): Hübscher Judith, Lüthy Lucas, Berger-Bächi Brigitte, Stutzmann Meier Patricia
Primary Institution: Institute of Medical Microbiology, University of Zürich, Zürich, Switzerland
Hypothesis
What is the phylogenetic distribution and membrane topology of the LytR-CpsA-Psr protein family?
Conclusion
The LytR-CpsA-Psr domain is unique to bacteria and may have functional differences among its diverse subgroups.
Supporting Evidence
- LytR-CpsA-Psr proteins were found in all Gram-positive organisms except for Mollicutes.
- Most Gram-negative organisms did not contain LytR-CpsA-Psr family members.
- PhoA fusion experiments confirmed membrane topology predictions.
Takeaway
This study looked at a group of proteins in bacteria that help them survive antibiotics and other stresses. It found that these proteins are mostly found in bacteria with thick cell walls.
Methodology
The study involved sequence collection from databases and analysis of phylogenetic distribution and membrane topology predictions.
Limitations
The specific functions of the LytR-CpsA-Psr proteins are still not fully understood.
Digital Object Identifier (DOI)
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