Study of Murine Guanylate Binding Proteins
Author Information
Author(s): Kresse Alexandra, Konermann Carolin, Degrandi Daniel, Beuter-Gunia Cornelia, Wuerthner Jan, Pfeffer Klaus, Beer Sandra
Primary Institution: Heinrich-Heine-University
Hypothesis
The study aims to characterize the genomic organization and localization of murine guanylate binding proteins (mGBPs).
Conclusion
The study identifies and characterizes eleven mGBP family members and their genomic organization on chromosomes 3 and 5.
Supporting Evidence
- The study identified a new mGBP locus named mGbp11.
- The mGBP genes are arranged in two clusters located on chromosomes 3 and 5.
- The mGBPs share a highly similar genomic structure.
Takeaway
Scientists studied a group of proteins in mice that help fight infections, finding new members and how they are organized in the genome.
Methodology
The study used bacterial artificial chromosome (BAC) analyses, expressed sequence tag (EST) analyses, and RT-PCR to investigate the genomic organization of mGBPs.
Digital Object Identifier (DOI)
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