Inositol Transporters in Alzheimer's Disease Mouse Model
Author Information
Author(s): Fenili Daniela, Weng Ying-Qi, Aubert Isabelle, Nitz Mark, McLaurin JoAnne
Primary Institution: University of Toronto
Hypothesis
The study aims to determine the effects of aging and Alzheimer's disease-like amyloid pathology on sodium/myo-inositol transporter expression in the brain.
Conclusion
Inositol transporter levels are stably expressed as a function of age, and expression is unaltered with disease pathology in the TgCRND8 mouse.
Supporting Evidence
- Elevations in brain inositol levels occur across a concentration gradient as a result of active transport from the periphery.
- Disease pathology did not alter transporter expression in the cortex or hippocampus.
- For SMIT1, cerebellar levels were significantly higher than cortical and hippocampal levels at 4 and 6 months.
Takeaway
The study found that certain transporters in the brain that help move inositol, a type of sugar, do not change with age or Alzheimer's disease in mice.
Methodology
QPCR was used to examine expression of the two transporters in the cortex, hippocampus, and cerebellum of TgCRND8 mice compared to non-transgenic littermates.
Limitations
The study primarily focused on a specific mouse model and may not fully represent human conditions.
Participant Demographics
TgCRND8 mice and non-transgenic littermates at 2, 4, and 6 months of age.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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