Stimulation of tumour growth by wound-derived growth factors
1999
Wound Fluid and Tumor Growth
publication
Evidence: moderate
Author Information
Author(s): Abramovitch R, Marikovsky M, Meir G, Neeman M
Primary Institution: The Weizmann Institute of Science
Hypothesis
The study aims to determine how wound-derived growth factors influence tumor vascularization and progression.
Conclusion
Wound fluid accelerates tumor growth and vascularization in glioma cells, suggesting potential therapeutic targets.
Supporting Evidence
- Wound fluid from injuries reduced the time for vascularization and growth of glioma spheroids.
- Wound fluid was found to promote endothelial cell proliferation.
- Two key growth factors in wound fluid were identified as major contributors to tumor growth.
Takeaway
When you get hurt, your body releases fluids that can make tumors grow faster.
Methodology
The study used MRI to observe the effects of wound fluid on glioma spheroids implanted in mice.
Digital Object Identifier (DOI)
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