Association Study of Serine Racemase Gene with Methamphetamine Psychosis
Author Information
Author(s): Yokobayashi E, Ujike H, Kotaka T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N, Kuroda S
Primary Institution: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hypothesis
The study investigates the association between genetic variants of the serine racemase gene and methamphetamine psychosis.
Conclusion
The serine racemase gene did not affect susceptibility to methamphetamine use disorders, but it was associated with better prognosis and less multi-substance abuse in certain genotypes.
Supporting Evidence
- Genetic variants of glutamate-related genes were previously associated with methamphetamine psychosis.
- Patients with C-positive genotypes of rs408067 showed better prognosis after therapy.
- Lower d-serine levels may affect the prognosis of methamphetamine psychosis.
Takeaway
Researchers looked at a gene related to brain signaling to see if it affects how people react to methamphetamine. They found that some gene variations might help people recover better.
Methodology
The study analyzed three SNPs in the serine racemase gene in 225 patients with methamphetamine psychosis and 291 matched controls.
Limitations
The sample size was not large enough to exclude the possibility of a type I error.
Participant Demographics
225 patients (181 male, 44 female; mean age 37.5) and 291 controls (217 male, 57 female; mean age 37.6), all unrelated Japanese.
Statistical Information
P-Value
p=0.039 for prognosis, p=0.036 and p=0.029 for multi-substance abuse
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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