Finding Patterns in Gene Regulation
Author Information
Author(s): Arvind Rao, Hero Alfred O III, States David J, Engel James Douglas
Primary Institution: University of Michigan
Hypothesis
The discovery of these motifs would enable the large-scale investigation for the tissue-specific regulatory role of any conserved sequence element identified from genome-wide studies.
Conclusion
The study presents a method for identifying tissue-specific regulatory motifs that can help in understanding gene expression.
Supporting Evidence
- Motif discovery is crucial for understanding gene expression.
- The proposed method can identify novel motifs with potential regulatory functions.
- Identifying tissue-specific motifs can aid in studying development and disease.
Takeaway
This study helps scientists find special patterns in DNA that control how genes work in different types of cells.
Methodology
The study uses directed information for classification constrained motif discovery and a support vector machine classifier to identify tissue specificity.
Digital Object Identifier (DOI)
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