Biomarkers in Ductal Carcinoma In Situ with Microinvasion
Author Information
Author(s): Okumura Yasuhiro, Yamamoto Yutaka, Zhang Zhenhuan, Toyama Tatsuya, Kawasoe Teru, Ibusuki Mutsuko, Honda Yumi, Iyama Ken-ichi, Yamashita Hiroko, Iwase Hirotaka
Primary Institution: Kumamoto University
Hypothesis
What are the biological differences between ductal carcinoma in situ (DCIS) and DCIS with microinvasion (DCIS-Mi)?
Conclusion
DCIS-Mi shows slightly higher cell proliferation and enhanced apoptosis compared to DCIS, which may contribute to necrotic foci formation.
Supporting Evidence
- DCIS-Mi had a higher frequency of necrosis compared to DCIS.
- Survivin expression was significantly higher in DCIS-Mi than in DCIS.
- The apoptotic index tended to be higher in DCIS-Mi than in DCIS.
- Multivariate analysis identified necrosis and survivin expression as independent factors associated with invasion.
Takeaway
This study looked at two types of breast cancer, finding that one type (DCIS-Mi) grows a bit faster and has more cell death than the other (DCIS).
Methodology
The study compared 52 cases of pure DCIS and 28 cases of DCIS-Mi using immunohistochemistry and TUNEL methods.
Limitations
The study focused only on intraductal components and did not evaluate invasive components due to their small size.
Participant Demographics
Median age was 56 years for DCIS and 50 years for DCIS-Mi, with a range of 32 to 86 years.
Statistical Information
P-Value
0.0017 for necrosis, 0.0048 for survivin expression
Confidence Interval
1.47–22.7 for necrosis, 1.11–17.2 for survivin
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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