Neutrophil-Lymphocyte Ratio and Urine Albumin-Creatinine Ratio in Type 2 Diabetes
Author Information
Author(s): Muacevic Alexander, Adler John R, Upadhyayula Sai K, Ubaru Sharath, Raajeshwi P., Ajavindu C.N., Rao Anirudh B
Primary Institution: Kempegowda Institute of Medical Sciences, Bengaluru, IND
Hypothesis
Can neutrophil-lymphocyte ratio (NLR) and urine albumin-creatinine ratio (UACR) predict microvascular complications in patients with type 2 diabetes mellitus?
Conclusion
The study found that UACR is a strong predictor of diabetic neuropathy and retinopathy, while NLR showed less predictive power.
Supporting Evidence
- UACR achieved an accuracy of 91% for diabetic retinopathy and 81.5% for diabetic neuropathy.
- NLR showed 85% accuracy for diabetic retinopathy but was not significant in multivariate analyses.
- Logistic regression identified UACR, duration of diabetes, and HbA1C as significant predictors of complications.
- Patients with higher NLR and UACR quartiles had a higher prevalence of diabetic complications.
Takeaway
Doctors can use two simple tests, NLR and UACR, to help find out if people with diabetes might have serious problems with their eyes or nerves.
Methodology
This cross-sectional study measured NLR and UACR in 130 patients with type 2 diabetes to evaluate their predictive value for diabetic neuropathy and retinopathy.
Potential Biases
Potential confounding factors such as medication use and comorbidities were not fully accounted for.
Limitations
The study's cross-sectional design limits causal inferences, and the sample may not represent the broader population.
Participant Demographics
The sample consisted of 54% male and 46% female participants, with a mean age of 57.2 years.
Statistical Information
P-Value
p<0.001
Confidence Interval
95%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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