Amniocentesis and Birth Weight Risks
Author Information
Author(s): Vincenzo Mazza, Mariangela Pati, Emma Bertucci, Carlotta Cani, Silvia Latella, Giancarlo Gargano, Antonio Percesepe, Annibale Volpe
Primary Institution: University of Modena and Reggio Emilia
Hypothesis
Does second trimester amniocentesis increase the risk of very low birth weight (VLBW) and extremely low birth weight (ELBW)?
Conclusion
The study found no significant increase in the risk of VLBW and ELBW associated with second trimester amniocentesis.
Supporting Evidence
- The odds ratios for VLBW and ELBW did not show any statistically significant risk.
- The study included a large sample size of 4,877 women undergoing amniocentesis.
- The control group consisted of 37,642 women who delivered without undergoing amniocentesis.
Takeaway
This study shows that having an amniocentesis in the second trimester doesn't make babies more likely to be very small at birth.
Methodology
The study analyzed records of 4,877 women who underwent amniocentesis and compared outcomes with a control group of 37,642 women who did not undergo the procedure.
Potential Biases
Potential bias from excluding women who underwent amniocentesis elsewhere.
Limitations
The study only included Caucasian women and may not be generalizable to other populations.
Participant Demographics
Caucasian women with singleton pregnancies.
Statistical Information
Confidence Interval
VLBW: 0.72–1.54; ELBW: 0.7–1.95
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website