Distribution of tbpB gene variants among Neisseria species
Author Information
Author(s): Harrison Odile B, Maiden Martin CJ, Rokbi Bachra
Primary Institution: The Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford
Hypothesis
The isotype I tbpB gene may also be shared between non-pathogenic Neisseria and ST-11 meningococci.
Conclusion
The study reveals that the isotype I tbpB gene is present among diverse Neisseria species, indicating a horizontal genetic transfer event.
Supporting Evidence
- Two families of isotype I tbpB were identified, indicating genetic diversity.
- Three isotype II tbpB families were also identified, showing further genetic variation.
- Phylogenetic analysis revealed distinct clusters of tbpB genes among Neisseria species.
Takeaway
This study found that a specific gene important for iron acquisition is shared between harmful and harmless Neisseria bacteria, suggesting they may have exchanged genetic material.
Methodology
The study involved isolating and sequencing tbpB genes from various Neisseria species and performing phylogenetic analysis.
Limitations
Functional assessment of the protein was beyond the scope of the study.
Digital Object Identifier (DOI)
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