DNA Methylation Models of Protein Abundance Across the Lifecourse
Author Information
Author(s): Scott Waterfield, Paul Yousefi, Matt Suderman
Primary Institution: University of Bristol, Bristol, UK
Hypothesis
How do episcores trained in later adulthood perform across the lifecourse and to what extent can DNA methylation capture age-specific variation in protein abundance?
Conclusion
Episcores perform better at older ages than in children, capturing non-genetic variation in protein abundance across the lifecourse.
Supporting Evidence
- Of the 14 Gadd episcores, 10 generated estimates associated with abundance in middle age.
- Eight episcores explained variation beyond genotype in adulthood.
- At age 24, 31 proteins could be modelled by DNAm, 19 beyond genotype.
Takeaway
This study looks at how DNA changes can help us understand protein levels in our bodies as we grow up, showing that these changes are more helpful for adults than for kids.
Methodology
The study evaluated 14 previously published DNA methylation models of protein abundance in a large adult population using the Avon Longitudinal Study of Parents and Children (ALSPAC).
Potential Biases
Potential bias due to relatedness between mothers and children and autocorrelation between time points.
Limitations
The study had small and highly variable sample sizes, which may affect statistical power and comparability of results.
Participant Demographics
Participants included children and their mothers from the Avon Longitudinal Study of Parents and Children (ALSPAC) in south-west England.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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