Tumor Growth Delay After Radiation in Melanoma
Author Information
Author(s): E.K. Rofstad, T. Brustad
Primary Institution: Norsk Hydro's Institute for Cancer Research and The Norwegian Cancer Society, The Norwegian Radium Hospital, Montebello, Oslo 3, Norway.
Hypothesis
The study investigates the variability in radiation response among different lines of human melanoma xenografts and its correlation with tumor growth parameters.
Conclusion
The most radioresistant melanomas have longer volume-doubling times, lower growth fractions, higher cell loss factors, and lower vascular density.
Supporting Evidence
- The radiation response varied considerably among the melanoma lines studied.
- The most radioresistant melanomas showed longer volume-doubling times and lower vascular density.
- Specific growth delay after 15 Gy was correlated to the surviving fraction measured in vitro after 6 Gy.
Takeaway
Some types of melanoma are tougher against radiation than others, and this study looks at why that is by comparing their growth and structure.
Methodology
Five different human melanoma lines were grown in athymic mice and exposed to single doses of radiation, followed by analysis of tumor growth delay.
Limitations
The study does not account for the effects of different histological types of tumors on radiation response.
Participant Demographics
Melanomas derived from metastases of five different patients.
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