Anti-Melanogenic Properties of Triglochin maritima Extracts
Author Information
Author(s): Lee Won-Hwi, Ha Yuna, Park Jeong-In, Joh Won Bae, Park Mira, Kim Jang Kyun, Jeon Hee-Kyung, Kim Youn-Jung, Tsoupras Alexandros
Primary Institution: Incheon National University
Hypothesis
This study aimed to explore the anti-melanogenic potential of Triglochin maritima extracts.
Conclusion
Triglochin maritima extracts significantly inhibit melanin synthesis and tyrosinase activity through the CREB/MAPK signaling pathway.
Supporting Evidence
- TME and TME-EA significantly decreased melanin and tyrosinase activity in α-MSH-stimulated B16F10 cells.
- TME-EA showed comparable effects to arbutin in inhibiting melanin production.
- TME-EA down-regulated melanogenesis genes and reduced CREB, p-38, and JNK phosphorylation.
- Luteolin was identified as a potential active ingredient in T. maritima extracts.
Takeaway
This study found that a plant called Triglochin maritima can help reduce skin darkening by stopping the production of a pigment called melanin.
Methodology
The study used MTT assays to assess cytotoxicity and measured melanin content and tyrosinase activity in B16F10 cells treated with different extracts.
Limitations
The study did not identify or quantify other potential active ingredients besides luteolin, and further research is needed to analyze extracts from different seasons and locations.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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