Effects of Hyperoxia on Microcirculation in Pigs with Abdominal Aneurysm
Author Information
Author(s): Cundrle I Jr, Sramek V, Suk P, Hruda J, Krbusik J, Helan M, Vlasin M, Matejovic M, Pavlik M
Primary Institution: St Anns University Hospital Brno, Czech Republic
Hypothesis
The study aimed to evaluate the effect of hyperoxia on sublingual and ileostomal microcirculation during hemorrhagic and reperfusion shock in a porcine model simulating the rupture of an abdominal aortic aneurysm.
Conclusion
Hyperoxia may compromise microcirculation during bleeding but improve it during resuscitation in a model of ruptured abdominal aortic aneurysm.
Supporting Evidence
- Sublingual microcirculation showed significant increases in density parameters in the hyperoxia group.
- Ileostomal microcirculation showed significant declines in density and perfusion parameters in the hyperoxia group.
Takeaway
When pigs with a ruptured artery were given extra oxygen, it helped their blood flow after they were treated, but it made things worse while they were bleeding.
Methodology
Pigs were randomized into four groups and microcirculation was recorded using SDF imaging at various time points during the experiment.
Participant Demographics
Porcine model
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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