Trends in cancer of the cervix uteri in Sweden following cytological screening
1999
Cervical Cancer Trends in Sweden After Screening
publication
Evidence: moderate
Author Information
Author(s): Bergström R, Sparén P, Adami H-O
Primary Institution: Department of Information Sciences, Division of Statistics, Uppsala University
Hypothesis
Has screening reduced the incidence of adenocarcinomas of the cervix?
Conclusion
Screening has significantly reduced the incidence of squamous cell cancer, but not adenocarcinomas.
Supporting Evidence
- The incidence of reported cancer in situ increased rapidly during 1958–1967.
- Incidence rates of squamous cell cancer decreased by 4–6% yearly in women aged 40–64 after 1968.
- An age-cohort model indicated a stable 70–75% reduction in incidence for women born 1940 and later.
- The incidence of adenocarcinomas doubled during the 35-year study period.
- The mortality rate increased by 3.6% before 1968 and decreased by 4.0% yearly thereafter.
Takeaway
This study looked at how cervical cancer rates changed in Sweden after starting screening. It found that screening helped lower one type of cancer but didn't affect another type.
Methodology
Analyzed Swedish nationwide data on incidence and mortality using Poisson-based age-period-cohort models.
Digital Object Identifier (DOI)
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