Rapid detection and curation of conserved DNA via enhanced-BLAT and EvoPrinterHD analysis
2008
EvoPrinterHD: A Tool for Detecting Conserved DNA Sequences
publication
Evidence: high
Author Information
Author(s): Yavatkar Amarendra S, Lin Yong, Ross Jermaine, Fann Yang, Brody Thomas, Odenwald Ward F
Primary Institution: NINDS, NIH, Bethesda, Maryland, USA
Hypothesis
EvoPrinterHD can enhance the detection of conserved DNA sequences across evolutionarily distant species.
Conclusion
EvoPrinterHD is a fast, high-resolution tool that improves the identification of conserved sequences essential for gene regulation.
Supporting Evidence
- EvoPrinterHD detects up to 75% more conserved bases than the original EvoPrinter.
- It holds over 112 billion base pairs of indexed genomes in memory.
- The tool allows for rapid extraction and curation of conserved sequences.
- EvoPrinterHD can identify unique or shared sequences in bacterial genomes.
Takeaway
EvoPrinterHD helps scientists find important DNA sequences that are the same in different animals, making it easier to study how genes work.
Methodology
EvoPrinterHD uses enhanced-BLAT algorithms to automatically generate comparative genomic analyses from a single input sequence.
Digital Object Identifier (DOI)
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