No Evidence of Neospora caninum Infection in Humans in England
Author Information
Author(s): McCann Catherine M., Vyse Andrew J., Salmon Roland L, Thomas Daniel, Williams Diana J.L., McGarry John W., Pebody Richard, Trees Alexander J.
Primary Institution: University of Liverpool
Hypothesis
Is there any evidence of human exposure to Neospora caninum in England?
Conclusion
The study found no evidence of human exposure to Neospora caninum in both a high-risk population and the general population in England.
Supporting Evidence
- 3,232 serum samples from the general population showed no evidence of exposure.
- 518 serum samples from a high-risk group also showed no evidence of exposure.
- All samples with >20% inhibition in the inhibition ELISA failed to give positive fluorescence results.
Takeaway
The study tested a lot of blood samples from people in England and found that no one had been infected with a parasite called Neospora caninum.
Methodology
Retrospective testing of serum samples using immunofluorescence antibody testing and ELISA.
Potential Biases
Selection bias in the HPA sera collection is unlikely due to free access to healthcare.
Limitations
The study may not account for regional differences in infection prevalence.
Participant Demographics
Samples included 3,232 from the general population and 518 from a high-risk group, with a median age range of 41-50 years.
Statistical Information
Confidence Interval
5% confidence interval [CI] 78.94–80.58
Digital Object Identifier (DOI)
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