Thymidine Phosphorylase Gene Expression in Ovarian Cancer
Author Information
Author(s): Hata K, Kamikawa T, Arao S, Tashiro H, Katabuchi H, Okamura H, Fujiwaki R, Miyazaki K, Fukumoto M
Primary Institution: Shimane Medical University
Hypothesis
The expression of the thymidine phosphorylase gene is associated with the progression and prognosis of epithelial ovarian cancer.
Conclusion
Higher levels of thymidine phosphorylase gene expression are linked to worse prognosis in ovarian cancer patients.
Supporting Evidence
- TP gene expression was significantly higher in stage III–IV compared to stage I–II (P = 0.0005).
- Histological grade was significantly associated with TP gene expression (P = 0.008).
- Patients with high TP gene expression had a significantly worse prognosis (P = 0.021).
- TP gene expression levels ranged from 0.19 to 5.38, with a median of 0.93.
Takeaway
This study found that a gene related to cancer growth is more active in patients with more severe ovarian cancer, which could help doctors understand how aggressive the cancer is.
Methodology
TP gene expression was analyzed using polymerase chain reaction of RNA after reverse transcription.
Participant Demographics
Patients included 27 with serous, 10 with mucinous, 12 with endometrioid, 5 with clear cell, and 2 with undifferentiated ovarian cancer.
Statistical Information
P-Value
0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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