Reduced Fhit Expression and Mismatch Repair Deficiency in Colorectal Cancer
Author Information
Author(s): Andachi H, Yashima K, Koda M, Kawaguchi K, Kitamura A, Hosoda A, Kishimoto Y, Shiota G, Ito H, Makino M, Kaibara N, Kawasaki H, Murawaki Y
Primary Institution: Tottori University, Japan
Hypothesis
Is reduced Fhit expression associated with mismatch repair deficiency in advanced colorectal carcinoma?
Conclusion
Reduced Fhit expression is significantly associated with the absence of mismatch repair protein expression in advanced colorectal carcinomas.
Supporting Evidence
- Reduced Fhit expression was noted in 34.6% of advanced colorectal carcinomas.
- Loss of mismatch repair protein expression was detected in 40.4% of colorectal carcinomas.
- Reduced Fhit expression was significantly associated with absence of mismatch repair protein expression.
Takeaway
This study found that when a protein called Fhit is less present in colorectal cancer, it often means that another important repair system in the cell is not working properly.
Methodology
Immunohistochemical analysis of Fhit, Msh2, Mlh1, and p53 expression in tumor samples.
Potential Biases
Potential bias due to the retrospective nature of the study and the reliance on immunohistochemical staining.
Limitations
The study excluded patients with familial adenomatous polyposis but did not exclude those with hereditary non-polyposis colorectal cancer, which may affect results.
Participant Demographics
27 male and 25 female patients aged 51 to 90 years, mean age 67.4 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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