Homocysteine and Cardiometabolic Multimorbidity in Chinese Adults
Author Information
Author(s): Li Ling, Wang Jia, Li Jing, Li Minqi, Wang Jie, Long Tianyao, Zhengliu Yangyi, Tan Xuan, Peng Yiwei, Hong Xiuqin
Primary Institution: Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University
Hypothesis
What is the effect of plasma homocysteine on cardiometabolic multimorbidity among Chinese adults?
Conclusion
High levels of plasma homocysteine are associated with a higher risk of cardiometabolic multimorbidity among Chinese adults.
Supporting Evidence
- High plasma homocysteine levels were linked to a 183% increased risk of cardiometabolic multimorbidity.
- The largest effect combination of cardiometabolic multimorbidity was found in individuals with diabetes, hypertension, and coronary heart disease.
- 64.66% of the cardiometabolic multimorbidity risk was attributable to high levels of plasma homocysteine.
Takeaway
If you have high levels of a substance called homocysteine in your blood, you might get more than one health problem at the same time, like diabetes and heart disease.
Methodology
A community-based cross-sectional study combined with a matched case-control study using propensity score methods.
Potential Biases
Self-reported lifestyle factors may introduce recall bias.
Limitations
The study's cross-sectional design limits causal inferences, and the sample may not be generalizable beyond Hunan Province.
Participant Demographics
Mean age of 54.6 years, 41% male and 59% female.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 1.84–4.36
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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