Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans
2011
Discovery of a New Splice Variant of PIP5KIγ in Rodents and Humans
publication
Evidence: moderate
Author Information
Author(s): Xia Yang, Robin F. Irvine, Maria-Luisa Giudici
Primary Institution: Department of Pharmacology, University of Cambridge
Hypothesis
This study investigates splice variation in the lipid kinase PI4P 5-kinase Iγ.
Conclusion
The study identifies a new splice variant of PIP5KIγ in rodents and confirms its expression in humans.
Supporting Evidence
- A new splice variant of PIP5KIγ was discovered in rodents.
- This variant shows a wide tissue distribution in mice.
- Humans also express this new splice variant.
- Another known splice variant previously thought to be rodent-specific is also found in humans.
Takeaway
Scientists found a new version of a protein that helps cells communicate, and this version is found in both mice and humans.
Methodology
The study involved RNA extraction, reverse-transcription PCR, and sequencing to identify splice variants.
Limitations
The study does not provide extensive data on the physiological significance of the new splice variant.
Digital Object Identifier (DOI)
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