Myostatin Levels in Congenital Heart Disease
Author Information
Author(s): Bish Lawrence T., George Isaac, Maybaum Simon, Yang Jonathan, Chen Jonathan M., Sweeney H. Lee
Primary Institution: University of Pennsylvania School of Medicine
Hypothesis
The study aims to quantify myostatin expression in congenital heart disease (CHD) patients with varying degrees of myocardial dysfunction.
Conclusion
Myostatin expression is increased in congenital heart disease, and its ratio with IGF-1 rises as ventricular function deteriorates.
Supporting Evidence
- Myostatin expression was significantly increased in LV-OHT compared to RV-OHT and RVOT.
- Myostatin levels were more than double in decompensated biventricular heart failure compared to both OHT and RVOT.
- The myostatin/IGF-1 ratio was associated with ventricular dysfunction.
Takeaway
Myostatin, a protein that controls muscle growth, is found in higher amounts in children with heart problems, especially when their heart isn't working well.
Methodology
Myocardial biopsies were collected from four patient cohorts and analyzed for myostatin and IGF-1 expression using Western blot.
Potential Biases
Potential bias due to the small cohort and the nature of the patient selection.
Limitations
The study has a small sample size and is limited to pediatric patients.
Participant Demographics
Participants included adults and pediatric patients with congenital heart disease, with ages ranging from infants to adults.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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