Effects of Oreocnide integrifolia on Diabetes in Mice
Author Information
Author(s): Ansarullah, Jayaraman Selvaraj, Hardikar Anandwardhan A., Ramachandran A. V.
Primary Institution: M. S. University of Baroda
Hypothesis
Does Oreocnide integrifolia extract induce insulin secretion and affect the insulin-signaling pathway in diabetic mice?
Conclusion
The study shows that Oreocnide integrifolia extract can improve insulin secretion and glucose regulation in diabetic mice.
Supporting Evidence
- OI extract supplementation reduced body weight gain in diabetic mice.
- Plasma glucose levels were significantly lower in OI extract-treated mice compared to diabetic controls.
- Immunoblot analysis showed improved IRS-1 expression in muscles of OI extract-treated animals.
Takeaway
This study found that a plant called Oreocnide integrifolia can help mice with diabetes by making their bodies better at using insulin.
Methodology
C57BL/6J mice were divided into three groups: control, diabetic with high-fat diet, and diabetic with 3% OI extract for 24 weeks; insulin secretion and signaling pathways were analyzed.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
C57BL/6J male mice, aged 4-5 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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