Unassigned MURF1 of kinetoplastids codes for NADH dehydrogenase subunit 2
2008
MURF1 Protein in Kinetoplastids and Its Role as NADH Dehydrogenase Subunit 2
publication
Evidence: high
Author Information
Author(s): Kannan Sivakumar, Burger Gertraud
Primary Institution: Université de Montréal
Hypothesis
MURF1 is a highly derived distant homolog of NAD2.
Conclusion
The study provides convincing evidence that MURF1 is a highly derived homolog of NAD2.
Supporting Evidence
- MURF1 was predicted to be a divergent NADHdh subunit 2 (NAD2) by a machine-learning-based classifier.
- Profile HMM comparisons identified MURF1 as NAD2 with high confidence.
- No previously annotated nad2 gene was found in the mitochondrial or nuclear genomes of kinetoplastids.
Takeaway
Scientists studied a protein called MURF1 in certain tiny organisms and found out that it is actually a part of a bigger machine that helps these organisms breathe.
Methodology
The study used bioinformatics methods including sequence comparisons and profile HMM comparisons to analyze the MURF1 protein.
Digital Object Identifier (DOI)
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