Detecting Lymph Node Metastasis in Oesophageal Cancer
Author Information
Author(s): Kano M, Shimada Y, Kaganoi J, Sakurai T, Li Z, Sato F, Watanabe G, Imamura M
Primary Institution: Graduate School of Medicine, Kyoto University
Hypothesis
The study investigates the usefulness of the SCC antigen gene as a marker with RT-nested PCR to detect occult lymph node metastases of oesophageal cancer.
Conclusion
The RT-nested PCR method was found to be more effective in detecting lymph node metastases compared to traditional pathological and immunohistochemical examinations.
Supporting Evidence
- The RT-nested PCR detected 101 of SCC antigen producing cells in 107 peripheral blood mononucleocytes.
- The RT-nested PCR detected 65 lymph nodes, which was statistically more than the 36 detected by pathological examination and 45 by immunohistochemical examination.
Takeaway
This study shows that a special test can find hidden cancer in lymph nodes better than regular tests.
Methodology
The study analyzed 620 lymph nodes from 14 oesophageal cancer patients using RT-nested PCR and compared the results with pathological and immunohistochemical examinations.
Participant Demographics
Patients with oesophageal cancer.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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