An Investigation of 2'-Deoxyribonucleoside Cyanoboranes in Mice for Therapeutic Safety
1993
Therapeutic Safety of 2'-Deoxyribonucleoside Cyanoboranes in Mice
Sample size: 5
publication
Evidence: moderate
Author Information
Author(s): Iris H. Hall, Bruce S. Burnham, K.G. Rajendran, J.-J. Chang, Anup Sood, Bernard Spielvogel
Primary Institution: University of North Carolina Chapel Hill
Hypothesis
Are 2'-deoxyribonucleoside cyanoboranes safe for therapeutic use in mice?
Conclusion
The study found that 2'-deoxyribonucleoside cyanoboranes were nontoxic at therapeutic doses in mice.
Supporting Evidence
- All treated animals survived with slight reductions in body weight.
- No clinical chemistry values suggested organ-specific toxicity.
- LD50 values were greater than 1000 mg/kg for all compounds.
- Compounds showed no in vitro toxicity against human HCT-8 ileum cells.
- Modulation of white blood cell populations was observed.
Takeaway
The researchers tested a new drug on mice and found it didn't make them sick, even at higher doses.
Methodology
Mice were given different doses of the compounds for 7 days, and various health parameters were measured.
Limitations
The study was limited to acute toxicity and did not assess long-term effects.
Participant Demographics
CF1 male mice, approximately 28 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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