Stability of Methylnicotinate in Solution
Author Information
Author(s): Ross Brian M, Katzman Martin
Primary Institution: Northern Ontario School of Medicine, Lakehead University
Hypothesis
How long can solutions of methylnicotinate be stored before they degrade?
Conclusion
Methylnicotinate exhibits excellent chemical and biological stability in solution facilitating its use in clinical applications.
Supporting Evidence
- Methylnicotinate degrades at a rate of approximately 0.5% per annum.
- No significant difference in vasodilatatory response was found between batches stored for different lengths of time.
- The study used High Performance Liquid Chromatography to analyze the stability of methylnicotinate.
Takeaway
Methylnicotinate can stay good for a long time in water without losing its ability to work, which is helpful for doctors.
Methodology
The study analyzed the degradation of methylnicotinate in stored solutions using High Performance Liquid Chromatography and tested its vasodilatatory effects on healthy volunteers.
Limitations
The study's small sample size may have limited the ability to detect subtle effects of batch age on erythema.
Participant Demographics
8 healthy volunteers (4 male, 4 female, mean age 44 ± 12 years)
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% confidence interval was 0.001270% to 0.00172%
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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