Trends in Nasopharyngeal Carcinoma in Southern China
Author Information
Author(s): Jia Wei-Hua, Huang Qi-Hong, Liao Jian, Ye Weimin, Shugart YY, Liu Qing, Chen Li-Zhen, Li Yan-Hua, Lin Xiao, Wen Fa-Lin, Adami Hans-Olov, Zeng Yi, Zeng Yi-Xin
Primary Institution: Departments of Experimental Research, Cancer Center, Sun Yat-sen University, GuangZhou
Hypothesis
What are the trends in incidence and mortality of nasopharyngeal carcinoma (NPC) over a 20–25 year period in Sihui and Cangwu counties in southern China?
Conclusion
The incidence rates of NPC have largely remained stable in Sihui and Cangwu, with a slight increase in males in Cangwu, while a progressive decline in mortality was observed in females in Sihui.
Supporting Evidence
- The incidence rate of NPC has remained stable in Sihui over 25 years.
- A slight increase in incidence was observed in males in Cangwu.
- A progressive decline in mortality rate was observed in females in Sihui.
- The incidence in Sihui was 1.4 to 2.0 times higher than in Cangwu.
Takeaway
This study looked at how many people got sick and died from a type of throat cancer in two places in China over many years, finding that the number of new cases stayed about the same.
Methodology
Incidence and mortality rates were aggregated by 5-year age groups and 5 calendar years, adjusted by direct standardization according to the World Standard Population.
Potential Biases
There may be risks of bias due to the voluntary reporting of cancer cases and the lack of compulsory reporting laws.
Limitations
The study may be limited by the completeness of cancer registry data and potential misdiagnosis.
Participant Demographics
The populations in both counties are of Cantonese origin, with a total of 393,655 inhabitants in Sihui and 649,404 in Cangwu.
Statistical Information
P-Value
0.016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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