Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour
1994
Stable Energy Status in Rat Tumors Despite Blood Flow Changes
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): P. Vaupel, D.K. Kelleher, T. Engel
Primary Institution: Institute of Physiology & Pathophysiology, University of Mainz
Hypothesis
Do changes in tumour blood flow necessarily lead to changes in the bioenergetic status during normoglycaemia?
Conclusion
The study found that tumor energy status remains stable as long as blood flow does not fall below a certain threshold.
Supporting Evidence
- Stable energy status is maintained as long as blood flow is above 0.4-0.5 ml g-1 min-1.
- Acute changes in blood flow do not necessarily lead to changes in ATP levels if glucose is available.
- Similar findings have been observed in other experimental tumor systems.
Takeaway
Even if blood flow to a tumor changes a lot, the energy in the tumor can stay the same if the blood flow doesn't drop too low.
Methodology
Experiments were conducted on Sprague-Dawley rats with subcutaneous DS sarcoma tumors to measure blood flow, oxygenation, and energy status.
Participant Demographics
Sprague-Dawley rats, body weight: 310 ± 5 g
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website