5-Choice Continuous Performance Test: A Vigilance Test for Mice
Author Information
Author(s): Young Jared W., Light Gregory A., Marston Hugh M., Sharp Richard, Geyer Mark A.
Primary Institution: Department of Psychiatry, University of California San Diego
Hypothesis
C57BL/6J performance would be superior to DBA/2J mice in the 5C-CPT as measured by the sensitivity index measure from signal detection theory.
Conclusion
The 5C-CPT effectively differentiates between mouse strains in terms of vigilance performance, with C57BL/6J mice showing superior sensitivity compared to DBA/2J mice.
Supporting Evidence
- C57BL/6J mice exhibited superior sensitivity index levels compared to DBA/2J mice.
- A vigilance decrement was observed in both strains, more pronounced in DBA/2J mice.
- Increased response times were noted with increased attentional load.
Takeaway
This study created a test to see how well mice can pay attention, and found that one type of mouse is better at it than another.
Methodology
Mice were trained in the 5C-CPT, which includes both signal and non-signal trials to assess vigilance, and their performances were analyzed using signal detection theory.
Potential Biases
Potential response bias differences between mouse strains could affect performance outcomes.
Limitations
The task is self-paced, which may differ from traditional experimenter-paced tests.
Participant Demographics
Male C57BL/6J and DBA/2J mice, aged approximately 3 months.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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