Using Citrate Anticoagulation in Dialysis
Author Information
Author(s): Kalb R, Ammann J, Slowinski T, Morgera S, Kindgen-Milles D
Primary Institution: University Hospital, Düsseldorf, Germany
Hypothesis
Is regional citrate anticoagulation safe and effective for high-volume continuous venovenous hemodialysis in patients requiring intensified treatment?
Conclusion
Regional citrate anticoagulation for CVVHD is safe and effective for delivering a high dialysis dose and controlling acid-base status.
Supporting Evidence
- The mean dialysis dose was 49 ml/kg/hour during the first 72 hours.
- Mean filter lifetime was 78 hours.
- In-hospital mortality was 57% among the patients.
Takeaway
This study shows that using citrate instead of heparin during dialysis can help patients get better treatment without serious side effects.
Methodology
A prospective observational study enrolling 75 patients with acute kidney failure, applying high-volume CVVHD using RCA for at least 72 hours.
Limitations
The study did not investigate RCA in patients with severe metabolic derangements or obesity.
Participant Demographics
Patients with acute kidney failure following extended surgery.
Digital Object Identifier (DOI)
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