Genetic Variants in TRPM6 and TRPM7, Magnesium Intake, and Type 2 Diabetes Risk in Women
Author Information
Author(s): Song Yiqing, Hsu Yi-Hsiang, Niu Tianhua, Manson JoAnn E, Buring Julie E, Liu Simin
Primary Institution: Brigham & Women's Hospital, Harvard Medical School
Hypothesis
Common genetic variants in TRPM6 and TRPM7 are associated with risk of developing type 2 diabetes due to their critical functions on maintaining magnesium homeostasis.
Conclusion
Two common non-synonymous TRPM6 coding region variants may increase susceptibility to type 2 diabetes in women with low magnesium intake.
Supporting Evidence
- Women with low magnesium intake and specific TRPM6 gene variants had a significantly higher risk of type 2 diabetes.
- Overall, no robust association was found between individual SNPs and diabetes risk.
- Only one SNP in TRPM6 was significantly associated with diabetes risk in the recessive model.
Takeaway
This study looked at how certain genes and magnesium intake might affect the risk of diabetes in women. It found that women with specific gene variations and low magnesium intake had a higher risk of diabetes.
Methodology
A nested case-control study was conducted with 359 diabetes cases and 359 matched controls from the Women's Health Study over a median follow-up of 10 years.
Potential Biases
Population stratification may be a concern, but the study population was racially homogeneous.
Limitations
The study had a relatively small sample size and may not have sufficient power to detect modest genetic effects.
Participant Demographics
Postmenopausal women, predominantly Caucasian, aged 45 years and older.
Statistical Information
P-Value
0.03
Confidence Interval
1.05–23.0
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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