Late-Life Disability Following the Look AHEAD Trial
Author Information
Author(s): Semelka Charles, Neiberg Rebecca, Huckfeldt Peter, Hayden Kathleen, Chen Haiying, Wagenknecht Lynne, Espeland Mark, Houston Denise
Primary Institution: Wake Forest University School of Medicine
Hypothesis
The study aims to describe the post-intervention impact on disability in older adults with type 2 diabetes and overweight/obesity.
Conclusion
The study found clinically relevant differences in late-life disability based on post-trial BMI status.
Supporting Evidence
- Disability increased in BADLs from 3.1% to 12.6% over the follow-up period.
- Disability in IADLs increased from 3.5% to 22.7%.
- Mobility disability increased from 21.9% to 46.7%.
- Participants with a BMI of 35+ had increased odds of disability.
Takeaway
Older adults with higher body weight had more trouble doing daily activities after a diabetes intervention, but the type of intervention didn't seem to matter.
Methodology
Disability was assessed using the Pepper Assessment Tool for Disability (PAT-D) and regression models were used to examine associations.
Participant Demographics
Mean age 68.7 years, 61% female, 69% White, 8% with CVD history.
Statistical Information
Confidence Interval
OR [95% CI]: 2.0 [1.5-2.8] for IADLs; 2.2 [1.7-2.9] for mobility.
Statistical Significance
p≥0.78
Digital Object Identifier (DOI)
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