Effects of Laser Light on Gum Disease in Mice
Author Information
Author(s): Braga Larissa Trarbach Figueiredo, Ribeiro Isadora Martins, Barroso Maria Eduarda de Souza, Kampke Edgar Hell, Neves Lorena Nascimento Santos, Andrade Sara Cecília, Barbosa Guilherme Heleodoro, Porto Marcella Leite, Meyrelles Silvana Santos
Primary Institution: Federal University of Espirito Santo (UFES)
Hypothesis
This study investigates the effects of photobiomodulation (PBM) on oxidative stress and inflammation in a periodontitis model using mice.
Conclusion
Photobiomodulation therapy reduced oxidative stress and inflammation in gingival tissues and showed potential systemic benefits in a murine model of periodontitis.
Supporting Evidence
- PBM reduced superoxide anions and hydrogen peroxide levels in gingival cells.
- Apoptosis in gingival cells was significantly reduced with PBM treatment.
- Systemic inflammation markers decreased in the PBM treated group.
- Pro-inflammatory cytokines IL-6 and IL-12p70 decreased, while IL-10 increased with PBM.
Takeaway
This study found that using a special light therapy on mice with gum disease helped reduce harmful substances and inflammation in their gums.
Methodology
C57BL/6 mice were divided into four groups and treated with PBM using an infrared diode laser, followed by analysis of oxidative stress and inflammatory markers.
Limitations
The study did not evaluate the long-term effects of PBM after treatment.
Participant Demographics
C57BL/6 mice, both sexes, aged 16 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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