Receptor Tyrosine Kinases in Kidney Development
2011
Receptor Tyrosine Kinases in Kidney Development
publication
Evidence: moderate
Author Information
Author(s): Song Renfang, El-Dahr Samir S., Yosypiv Ihor V.
Primary Institution: Tulane University Health Sciences Center
Hypothesis
Aberrant signaling via receptor tyrosine kinases (RTKs) is causally linked to congenital anomalies of the kidney and urinary tract (CAKUT).
Conclusion
The study reviews the role of receptor tyrosine kinases in kidney development and their implications in congenital kidney anomalies.
Supporting Evidence
- Congenital anomalies of the kidney and urinary tract (CAKUT) are common human birth defects.
- RTKs are key regulators of cellular processes such as proliferation and differentiation.
- Mutations in RTKs have been linked to various diseases, including cancers and CAKUT.
Takeaway
This study talks about how certain proteins help the kidneys grow properly, and if they don't work right, it can cause problems with the kidneys.
Methodology
The review summarizes current understanding of RTKs and their signaling pathways in kidney development.
Digital Object Identifier (DOI)
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