The combined effects of high-energy shock waves and cytostatic drugs or cytokines on human bladder cancer cells
1994
Effects of Shock Waves and Drugs on Bladder Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): K. Worle, P. Steinbach, F. Hofstiidter
Primary Institution: Universität Regensburg, Institut für Pathologie
Hypothesis
Can high-energy shock waves enhance the effectiveness of cytostatic drugs on bladder cancer cells?
Conclusion
Shock wave treatment can make certain bladder cancer cell lines more susceptible to chemotherapy drugs.
Supporting Evidence
- Shock wave treatment increased the sensitivity of bladder cancer cells to cis-platinum, mitomycin C, and actinomycin D.
- Cell lines sensitive to tumor necrosis factor alpha or interferon alpha were further sensitized by shock wave pretreatment.
- The antiproliferative effect was most pronounced after simultaneous shock wave and drug treatment.
Takeaway
This study found that using shock waves can help cancer drugs work better on bladder cancer cells.
Methodology
The study used in vitro experiments on bladder cancer cell lines, applying shock waves and various drugs to assess their combined effects on cell proliferation.
Limitations
The study was conducted in vitro, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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