Tacrolimus Toxicity in a Kidney Transplant Patient Treated with Paxlovid
Author Information
Author(s): Rycen Jack, Jefferis Julia, Mudge David
Primary Institution: Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia
Hypothesis
Can the use of Paxlovid in kidney transplant recipients lead to tacrolimus toxicity?
Conclusion
The acute kidney injury in the patient was caused by tacrolimus toxicity due to a drug interaction with Paxlovid.
Supporting Evidence
- Kidney transplant recipients have a higher risk of severe disease from COVID-19.
- Paxlovid can cause serious drug interactions due to its effect on the CYP3A enzyme.
- The patient experienced a significant increase in tacrolimus levels after starting Paxlovid.
Takeaway
A man who had a kidney transplant got very sick after taking a COVID-19 medicine called Paxlovid because it made another medicine he was taking too strong.
Methodology
Case report detailing the clinical presentation, treatment, and outcomes of a kidney transplant patient.
Limitations
The findings are based on a single case report, limiting generalizability.
Participant Demographics
57-year-old Caucasian male with a history of kidney transplantation.
Digital Object Identifier (DOI)
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