Proteins that bind methylated DNA and human cancer: reading the wrong words
2008
Proteins that bind methylated DNA and human cancer
publication
Author Information
Author(s): Lopez-Serra L, Esteller M
Primary Institution: Spanish National Cancer Research Centre (CNIO)
Conclusion
MBD proteins are involved in interpreting DNA methylation and can be targeted for cancer therapy.
Supporting Evidence
- MBD proteins bind to hypermethylated promoters in tumor suppressor genes.
- Altered DNA methylation patterns are common in cancer.
- Targeting MBD proteins may help in cancer therapy.
Takeaway
Some proteins help read the instructions in our DNA, and when they don't work right, it can lead to cancer. Scientists are looking at these proteins to help treat cancer.
Digital Object Identifier (DOI)
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